Warfarissimo is an online simulator of the effect of oral anticoagulant drugs warfarin and acenocoumarol in humans.
It computes an hour-by-hour INR graphic if you enter the anticoagulant doses and timings, and some other patient parameters.
Warfarissimo may help with the prediction of the INR response, and even allow optimisation of the range of INR variability in a particular case. However, we cannot offer any kind of warranty that its results will match those of any given patient.
It can be used freely, via this web site.
We welcome any kind of feedback, and especially examples of real cases in which the INR predicted by our model proves inaccurate.
Copyright (c) 2002--2006 Alexandru Corlan MD PhD
Mar 25, 2008
Paper on the next version of this simulator, that models the populational effect of warfarin, appears in PNAS
Mar 17, 2007
A short essay on warfarin and diet.
Aug 15, 2006
Independent experimental confirmation of higher INR fluctuations with uneven doses of acenocoumarol.
Dec 8, 2005
Forms for posting comments about your simulations.
Nov 24, 2005
Documentation on accessing previous simulation results.
Sep 15, 2005
Documentation on typical clinical application.
Mar 23, 2005
Mar 16, 2005
New dose/INR graphic output. PDF and older graphics now computed only on-demand, so response time was reduced to typically 8s for 14 days simulation.
Feb 2, 2005
Maximum duration of a simulated scenario extended from 20 to 100 days.
Jan 21, 2005
PDF output of INR curve and acenocoumarol doses.
Mar 14, 2004
Basic documentation added.
research paper on warfarissimo (in romanian).
Launch of this site.
First results obtained with the simulator.